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January 28, 2019

Ketogenic diet affects valproic acid, phenobarbital serum concentrations

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Serum concentrations of valproic acid and phenobarbital appear to be significantly affected in patients receiving a ketogenic diet, whereas concentrations of other antiepileptic drugs (AEDs) seem...
October 29, 2018

Pregabalin and opioids may result in a serious drug-drug interaction

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The risk of opioid-related death was significantly higher among patients coprescribed opioids and pregabalin (Lyrica—Pfizer), according to results of a nested case control study published in the...
July 16, 2018

Drug interactions are common among older adults receiving antiretroviral therapies

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A cross-sectional observational study published in the Journal of Acquired Immune Deficiency Syndromes involving 744 patients with HIV receiving antiretroviral treatment and at least one...
May 14, 2018

Common antibiotics do not appear to interact with hormonal contraceptives

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Clinical and pharmacokinetic studies do not appear to support an interaction between hormonal contraceptives (HCs) and most nonrifamycin antibiotics (e.g., penicillins/cephalosporins,...
March 13, 2018

PPIs decrease the effectiveness of hepatitis C antivirals

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Sustained virologic responses (SVRs) were lower in patients with hepatitis C taking direct-acting antivirals with proton pump inhibitors (PPIs) compared with those not receiving PPIs, according to...

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APhA DrugInfoLine (ISSN 2162-3015) is a weekly publication of, and is owned and copyrighted by the American Pharmacists Association, the national professional society of pharmacists. Materials in APhA DrugInfoLine do not neccessarily represent the policy, recommendations, or endorsement of APhA. The publisher, authors, editors, reviewers, and contributors have taken care to ensure that the information contained in APhA DrugInfoLine is accurate and current; however, they shall have no ability to any person or entity with regard to claims, losses, or damage caused or alleged to be caused, directly or indirectly by use of any information contained in the publication. All decisions about drug therapy must be based on independent judgement of the clinician.