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Emergence of Multidrug-Resistant HIV in U.S. Has Therapy Implications


A case report from New York describes isolation of a multidrug-resistant, dual-tropic strain of HIV-1 that produced rapid progression to AIDS. Because of the patient’s large number of high-risk sexual contacts and concurrent methamphetamine use, physicians in the city have been alerted to the possibility that this strain will produce infections and rapid-onset AIDS in other patients.


Markowitz M et al. Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report. Lancet. 2005;365:1031–8.