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Pharmacokinetics, Interactions Important in Antiretroviral Therapy

KEY POINT

Several recently published studies examined whether pregnancy, liver dysfunction, and green tea can affect the efficacy of highly active antiretroviral medication regimens by altering drug concentrations.

SOURCES

Nellen JF et al. Nelfinavir plasma concentrations are low during pregnancy. Clin Infect Dis. 2004;39:736–40.

Almond LM et al. The relationship between nevirapine plasma concentrations and abnormal liver function tests. AIDS Res Hum Retroviruses. 2004;20:716–22.

Kawai K et al. Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding. J Allergy Clin Immunol. 2003;112:951–7.

Donovan JL et al. Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers. Drug Metab Dispos. 2004;32:906–8.