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Pneumococcal Vaccine Beneficial in Children with HIV Infection


The safety and immunogenicity of polyvalent pneumococcal conjugate vaccines (PCVs) in infants and children with HIV infection have been largely unexplored and somewhat controversial, but two recent studies provide reassurance that these patients are benefitting from these immunizations.


Nachman S et al. Safety and immunogenicity of a heptavalent pneumococcal conjugate vaccine in infants with human immunodeficiency virus type 1 infection. Pediatrics. 2003;112:66–73. 

Klugman KP et al. A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engl J Med. 2003;349:1341–8. 

Edwards KM, Griffin MR. Great expectations for a new vaccine [perspective]. N Engl J Med. 2003;349:1312–4.