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Structured Treatment Interruptions: Costs, Autoimmunization, Resistance

KEY POINT

Researchers continue to examine the utility of structured treatment interruptions (STIs) in patients with HIV infection. STIs refer to the intermittent starting and stopping of therapy for HIV infection. They allow patients to take less medication (to lower cost or reduce adverse effects), they may be facilitating autoimmunization in patients with both acute and chronic infections, and they appear to allow some viral strains to revert to wild type after resistance develops. But STIs remain almost exclusively research tools with little or no definitive applicability in daily clinical practice, according to presentations made in July at the First International AIDS Society Conference on HIV Pathogenesis and Treatment in Buenos Aires, Argentina.

SOURCES

Presentations at the First International AIDS Society Conference on HIV Pathogenesis and Treatment. Buenos Aires, Argentina; July 8–11, 2001.