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What is the optimal CD4 count to start antiretroviral therapy?


Two recently published observational studies showed that starting antiretroviral therapy in patients with CD4 counts greater than 350 cells/mm3 was associated with a significantly lower risk of death and lower rates of AIDS and death.


Kitahata MM et al. Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med. 2009;360:1815–26. 

Sax PE et al. When to start antiretroviral therapy-ready when you are. N Engl J Med. 2009;360:1897–9. 

When to Start Consortium. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009;373:1352–63. 

Wood R et al. Should the CD4 threshold for starting ART be raised? Lancet. 2009;373:1314–6.