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Overuse Addressed for Nicotine Therapy, Oxymetazoline


Very few consumers are overusing nicotine replacement therapy (NRT) products, available without a prescription since 1996, reported authors who analyzed purchase patterns of American households. In another study that addressed a common perception about oxymetazoline nasal sprays, researchers found that normal subjects had no rebound congestion or tachyphylaxis during or after use of this medication three times daily for 4 weeks.


Shiffman S et al. Persistent use of nicotine replacement therapy: an analysis of actual purchase patterns in a population based sample. Tob Control. 2003;12:310–6. 

Watanabe H et al. Oxymetazoline nasal spray three times daily for four weeks in normal subjects is not associated with rebound congestion or tachyphylaxis. Rhinology. 2003;41:167–74.