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Study confirms phenylephrine ineffective for nasal congestion


Use of phenylephrine, at doses ranging from 10 mg to 40 mg every 4 hours, was found to be no better than placebo at relieving symptoms of nasal congestion in patients with seasonal allergic rhinitis (SAR), according to results of a large multicenter trial.


Meltzer EO et al. Oral phenyephrine HCl for nasal congestion in seasonal allergic rhinitis: a randomzied, open-label, placebo-controlled study. J Allergy Clin Immunol Pract. 2015;3:702–8.

Hatton RC et al. Over-the-counter phenylephrine: a placebo for nasal congestion [Editorial]. J Allergy Clin Immunol Pract. 2015;3:709–10.